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US 8,133,857 B2Granted
NOTCH inhibition in the treatment of atherosclerosis
AssigneeThe Brigham and Women's FHospital, Inc.
InventorMasanori Aikawa
Life of this patent
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Abstract
The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples.
Claims18
A method of treating a patient for atherosclerosis, comprising:
- a) assaying a biopsy sample from said patient for the amount or activity of NOTCH-3 receptor or Delta-like 4 (Dll4) and said amount or activity is elevated relative to one or more controls, and wherein said biopsy sample is cells or fluid derived directly from an atherosclerotic plaque;
- and
- b) administering systemically or locally to said patient a therapeutically effective amount of a compound that inhibits the binding of a ligand to the NOTCH-3 receptor, wherein said compound is not an RNA interfering agent or plasmid DNA.
Dependencies are inferred from the claim text.