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US 8,133,743 B2Granted
Phenobarbital derivatives useful in immunoassay
AssigneeRoche Diagnostics Operations, Inc.
InventorRaymond Hui
Life of this patent
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Abstract
Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche FPIA antibody specific for phenobarbital (“an antibody specific for phenobarbital”).
Claims4
A phenobarbital analog having a structure
A phenobarbital analog having a structure
A phenobarbital analog conjugate having a structure
- wherein R is aminodextran.
A phenobarbital analog conjugate having a structure
- wherein R is aminodextran.
Dependencies are inferred from the claim text.