Kit comprising an antibody to interleukin 17 receptor-like protein
AssigneeHuman Genome Sciences, Inc.
InventorsYanggu Shi, Stephen M. Ruben
Life of this patent
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Abstract
The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
Claims11
A kit comprising (i) an isolated antibody or fragment thereof that binds specifically to an Interleukin 17 Receptor-Like Protein, wherein the Interleukin 17 Receptor-Like Protein consists of an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence from position −19 to position +407 of SEQ ID NO:2;
- (b) the amino acid sequence from position −18 to position +407 of SEQ ID NO:2;
- (c) the amino acid sequence from position +1 to position +407 of SEQ ID NO:2;
- (d) the amino acid sequence from position +1 to position +271 of SEQ ID NO:2;
- (e) the amino acid sequence from position −5 to position +271 of SEQ ID NO:2;
- (f) the amino acid sequence of the full length protein encoded by the cDNA in ATCC Deposit No. 209198;
- (g) the amino acid sequence of the full length protein, excluding the N-terminal methionine residue, encoded by the cDNA in ATCC Deposit No. 209198;
- and
- (h) the amino acid sequence of the extracellular domain of the protein encoded by the cDNA in ATCC Deposit No. 209198;
- and
- (ii) an isolated polypeptide comprising a portion of SEQ ID NO:2 or a portion of the protein encoded by the cDNA in ATCC Deposit No. 209198 which binds specifically with said isolated antibody or fragment thereof.
Dependencies are inferred from the claim text.