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US 8,133,733 B2Granted
Nonviral vectors for delivering polynucleotides to target tissues
AssigneeGencia Corporation
InventorShaharyar Khan
Life of this patent
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Abstract
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal.
Claims10
A method for delivering a polynucleotide to one or more cells the method comprising:
- contacting the one or more cells with the polynucleotide packaged with a mitochondrial transcription factor A (TFAM) polypeptide fusion protein comprising a protein transduction domain, a cell-specific targeting signal and the TFAM polypeptide wherein the TFAM polypeptide comprises two HMG box domains and binds the polynucleotide.
Dependencies are inferred from the claim text.