Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
AssigneeBayer Schering Pharma Aktiengesellschaft
InventorRory A. J. Curtis
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Abstract
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims13
A method for identifying a compound which binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:2, the method comprising:
- a) contacting a sample comprising the polypeptide with a test compound under conditions suitable for binding;
- and
- b) determining whether the test compound binds to the polypeptide, thereby identifying a compound which binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.