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US 8,133,681 B2Granted
Chemo-immunotherapy method
AssigneeOxford Biomedica (UK) Limited
InventorsRichard Harrop, Michelle Kelleher, William Shingler, Susan Mary Kingsman, Miles William Carroll
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Abstract
A method of treating or preventing disease, said method comprising administering to a subject, simultaneously, sequentially or separately, an antigen and a chemotherapeutic agent or agents comprising the steps of: administering the chemotherapeutic agent or agents, and administering an antigen up to 6 weeks after the chemotherapeutic agent.
Claims5
A method of treating cancer in a patient, said method comprising:
- determining a baseline level of peripheral blood CD4+CD25+ Tregs of the patient,
- administering chemotherapy to the patient,
- determining a level of peripheral blood CD4+CD25+ Tregs of the patient during or after the chemotherapy, and
- immunizing the patient with an antigen when the patient has a reduced level of peripheral blood CD4+CD25+ Tregs,
- wherein the antigen is 5T4.
2 more elements
Dependencies are inferred from the claim text.