Form of administration based on crosslinked hydrophilic polymers
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsJohannes Bartholomaeus, Maria Cristina Vázquez Lantes
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Abstract
The invention relates to a film-shaped form of administration for topically administering at least one agent and/or nutrient to a living being. Said form of administration comprises at least one agent-containing and/or nutrient-containing layer that is based on crosslinked hydrophilic polymers which are crosslinked with at least one polyacrylic acid derivative.
Claims12
A process for producing a dosage form in film form for surface administration of at least one active ingredient and/or nutrient to a living creature comprising at least one active ingredient-containing and/or nutrient-containing layer based on hydrophilic polymers crosslinked with at least one polyacrylic acid derivative by building up individual layers successively on a smooth surface, characterized by the steps:
- a) simultaneous spraying of (1) an aqueous solution of the hydrophilic polymers and of the active ingredient and/or of the nutrient and (2) of an aqueous solution of the polyacrylic acid derivative, wherein the aqueous solution of the hydrophilic polymers and of the active ingredient and/or of the nutrient and aqueous solution of polyacrylic acid derivative are mixed after spraying and the hydrophilic polymers are crosslinked by the polyacrylic acid derivative in situ;
- and
- b) removal of the water by drying.
Dependencies are inferred from the claim text.