Systems and methods for delivery of a therapeutic agent
AssigneeThe Foundry, LLC
InventorsMark E. Deem, Hanson Gifford
Life of this patent
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Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Claims38
A system for delivering toxins to target cells in a mammalian target, said system comprising:
- a toxin consisting of a light chain of a neurotoxin fragment;
- a catheter or other structure adapted to introduce the toxin to a region adjacent the target cells;
- and
- an energy applicator configured to apply energy to the target cells at a level sufficient to cause pores to form in the cell membranes of the target cells to allow the toxin to pass through said pores into the target cells.
A system for delivering toxins to target cells in a mammalian target, said system comprising:
- a toxin delivery structure adapted to introduce a toxin to a region adjacent the target cells;
- an acoustic energy delivery element configured for applying acoustic energy to the target cells under conditions which causes poration of the cell membranes to enhance delivery of the toxin;
- and
- a toxin delivered by the catheter, the toxin consisting of a light chain of a neurotoxin fragment, wherein the delivery element is configured to deliver acoustic energy at a level sufficient to result in poration of the cell membranes to allow the toxin to pass into the target cells.
Dependencies are inferred from the claim text.