Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2
AssigneeNovartis Vaccine & Diagnostics Inc
InventorsJan zur Megede, Susan Barnett, Ying Lian, Susan Engelbrecht, Estrelita Janse van Rensburg, Thomas J. Scriba
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Abstract
The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.
Claims5
An expression cassette comprising a polynucleotide sequence encoding a polypeptide including an immunogenic human immunodeficiency virus (HIV) Env polypeptide, wherein the polynucleotide sequence has at least 90% identity to the full-length sequence of SEQ ID NO:21.
Dependencies are inferred from the claim text.