Inhibition of macrophage-stimulating protein receptor (RON) and methods of treatment thereof
AssigneeImClone LLC
InventorsDaniel Pereira, Jennifer O'Toole
Life of this patent
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Abstract
The invention provides antibodies or fragments thereof, including human antibodies, specific for Macrophage-Stimulating Protein Receptor (MSP-R or RON), which inhibit RON activation. Also provided are methods to inhibit RON, particularly the use of RON antibodies to treat diseases such as cancer.
Claims4
A method of treating cancer in a mammal, comprising administering to said mammal in need thereof an effective amount of the antibody or fragment comprising a heavy chain variable region having the sequence
- (SEQ ID NO:
- 6)
- EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYLMTWVRQAPGKGLEWV
- ANIKQDGSEKYYVDSVKGRFTISRDNAKNSLNLQMNSLRAEDTAVYYC
- TRDGYSSGRHYGMDVWGQGTTVIVSS
- and a light chain variable region having the sequence
- (SEQ ID NO:
- 8)
- EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLL
- IYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNW
- PRTFGQGTKVEIK,
- wherein the cancer is selected from the group consisting of tumor cells originating in the colon, pancreas, lung, and breast.
A method of treating cancer in a mammal, comprising administering to said mammal in need thereof an effective amount of the antibody or fragment thereof comprising two heavy chains having the sequence
- (SEQ ID NO:
- 50)
- EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYLMTWVRQAPGKGLEWV
- ANIKQDGSEKYYVDSVKGRFTISRDNAKNSLNLQMNSLRAEDTAVYYC
- TRDGYSSGRHYGMDVWGQGTTVIVSSASTKGPSVFPLAPSSKSTSGGT
- AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT
- VPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELL
- GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVE
- VHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAP
- IEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAV
- EWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSV
- MHEALHNHYTQKSLSLSPGK
- and two light chains having the sequence
- (SEQ ID NO:
- 51)
- EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLLI
- YDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPR
- TFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA
- KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVY
- ACEVTHQGLSSPVTKSFNRGEC,
- wherein the cancer is selected from the group consisting of tumor cells originating in the colon, pancreas, lung, and breast.
Dependencies are inferred from the claim text.