Hemostatic materials and dressing
AssigneeLifebond Ltd.
InventorsOrahn Preiss-Bloom, Ishay Attar
Life of this patent
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Abstract
An adhesive material comprising gelatin and a non-toxic cross-linking material such as transglutaminase. The adhesive material is useful for medical purposes as hemostatic products. The hemostatic products are useful for the treatment of wounded tissue.
Claims15
A method of treating a wounded tissue, comprising applying to said tissue a composition comprising gelatin and a non-toxic cross-linking agent, wherein said non-toxic cross-linking agent comprises transglutaminase, wherein said transglutaminase is included as part of a transglutaminase composition and the weight ratio of gelatin to transglutaminase composition is in a range of from about 1:10 to about 100:1, wherein activity of said transglutaminase in the gelatin-transglutaminase composition is at least about 40 U/g of gelatin, and wherein said gelatin and said transglutaminase are mixed before being applied to said tissue in liquid form;
- inducing hemostasis in said wound;
- and forming a biomimetic clot through in-situ cross-linking of said gelatin to said tissue by said transglutaminase and through formation of an in-situ matrix by said cross-linking.
A method of treating a wounded tissue, comprising applying to said tissue a composition comprising providing gelatin and a non-toxic cross-linking agent as separated components, wherein said non-toxic cross-linking agent comprises transglutaminase, wherein said transglutaminase is included as part of a transglutaminase composition and the weight ratio of gelatin to transglutaminase composition is in a range of from about 1:10 to about 100:1, and wherein activity of said transglutaminase in the gelatin-transglutaminase composition is at least about 40 U/g of gelatin;
- mixing said gelatin and said transglutaminase to form a mixture;
- upon mixing said gelatin and said transglutaminase to form a mixture, applying said mixture to said wounded tissue;
- inducing hemostasis in said wounded tissue;
- and forming a biomimetic clot through in-situ cross-linking of said gelatin to said tissue by said transglutaminase and through formation of an in-situ matrix by said cross-linking.
Dependencies are inferred from the claim text.