Method of treating or preventing a disease or condition mediated by pathogenic IgG antibodies
AssigneeHansa Medical AB
InventorsLars Björck, Rikard Holmdahl, Kutty Selva Nandakumar
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Abstract
The invention provides use of an IdeS polypeptide, or a polynucleotide encoding an IdeS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies.
Claims13
A method of treating or preventing a disease or condition mediated by pathogenic IgG antibodies in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an Immunoglobulin G-degrading enzyme of S. pyogenes (IdeS) polypeptide, or a polynucleotide encoding an IdeS polypeptide, wherein said polynucleotide is incorporated in an expression vector.
A method of treating, ex vivo, blood taken from a patient suffering from a disease or condition mediated by pathogenic IgG antibodies, comprising contacting the blood with an IdeS polypeptide.
Dependencies are inferred from the claim text.