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AssigneeHealth Research, Inc.
InventorsRavindra K. Pandey, Zachary Grossman, Peter Kanter, Thomas J. Dougherty
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A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissue. The preferred compounds have the structural formula: where R1, R2, R2a R3, R3a R4, R5, R5a R6, R7, R7a, and R8 cumulatively contain at least two functional groups that will complex or combine with an MR imaging enhancing element or ion. The compound is intended to include such complexes and combinations and includes the use of such compounds for MR imaging and photodynamic therapy treatment of tumors and other hyperproliferative tissue.
A composition comprising a chemical combination of a photodynamic tetra-pyrrolic compound having a chlorin or bacteriochlorin structure having four pendant groups attached to at least one pyrrole ring, said compound being provided with a plurality of radionuclide element atoms connected to a plurality of functional groups that will complex or combine with an MR imaging enhancing element wherein each such functional group contains at least one -DTPA moiety.
Dependencies are inferred from the claim text.