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US 8,133,438 B2Granted
Flow paths comprising one or two porous beds
AssigneeGyros Patent AB
InventorsJohan Engström, Mats Inganäs, Gunnar Thorsén
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AssigneeGyros Patent AB
InventorsJohan Engström, Mats Inganäs, Gunnar Thorsén
Estimating the term…
A microfluidic device that comprises a microchannel structure in which there are one, two or more flow paths (101;201a,b;301a,a′,b) all of which comprises a porous bed I (104,204,304) that is common for all of the flow paths and exposes an immobilized reactant R that is capable of interacting with a solute S that passes through the bed. The characteristics are that at least one of the flow paths comprises/comprise a second porous bed II (105,205,305) that is placed upstream of porous bed I (104,204,304) and is dummy with respect to interaction with solute S but capable of interacting with a substance DS that is present in a liquid aliquot together with solute S and is capable of disturbing the result of the interaction between solute S and said immobilized reactant R. There is also disclosed a method utilizing the device and variant of the device in which the immobilized R is replaced with a generic affinity ligand LI and/or porous bed II exposes a generic ligand LII that may be different from LI.
A microfluidic device comprising a microchannel structure in which there are two or more flow paths all of which comprises a porous bed I that is common for all of the flow paths and is provided in a detection microcavity permitting measurement on the porous bed, which bed exposes an immobilized reactant R that is capable of interacting with a solute S that passes through the bed, wherein at least one of the flow paths comprises a second porous bed II that is placed upstream of porous bed I and is dummy with respect to interaction with solute S but capable of interacting with a substance DS that is present in a liquid aliquot together with solute S and is capable of disturbing the result of the interaction between solute S and said immobilized reactant R.
A microfluidic device comprising a microchannel structure that comprises two or more flow paths each of which comprises a porous bed I that is common for all of said flow paths and at least one of which comprises a porous bed II which is upstream of porous bed I, wherein porous bed I is provided in a detection microcavity permitting measurement on the porous bed, wherein both of porous bed I and porous bed II in said two or more flow paths comprises a solid phase material containing a generic ligand, and which further comprises a liquid router in the flow path between porous beds I and II, wherein the liquid router is connected to an exit microconduit.
Dependencies are inferred from the claim text.