Antifungal compounds containing benzothiazinone, benzoxazinone or benzoxazolinone and process thereof
AssigneesCouncil of Scientific and Industrial Research, FDC Limited
InventorsHanumant Bapurao Borate, Suleman Riyasaheb Maujan, Sangmeshwer Prabhakar Sawargave, Ramesh Ganesh Kelkar, Radhika Dilip Wakharkar, Mohan Anand Chandavarkar, Sharangi Ravinda Vaiude, Vinay Anant Joshi
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Abstract
The present invention discloses novel compounds of the Formula (1), comprising benzothiazinone, benzoxazinone or benzoxazolinone moieties having antifungal activity, method for preparing these compounds and the use of these compounds as antifungal agents in prevention and treatment of fungal infections, and pharmaceutical preparations containing these novel compounds.
Claims8
Antifungal compounds of Formula 1
- wherein X is oxygen or sulphur;
- R1 is H, Cl, Br, F, Me, OMe, Ac or NO2;
- R2 and R3 may be the same or different and each represents a hydrogen or a halogen selected from fluorine, chlorine or bromine;
- and n=0 or 1.
A process of preparing an antifungal compound, comprising reacting a compound of Formula 2 with an epoxide of Formula 3 in the presence of a base, as set forth in Scheme 1, to obtain an antifungal compound of Formula 1, as set forth in Scheme 1:
- wherein X is oxygen or sulphur;
- R1 is H, Cl, Br, F, Me, OMe, Ac or NO2;
- R2 and R3 may be the same or different and each represent a hydrogen or a halogen selected from fluorine, chlorine or bromine;
- and
- n=0 or 1.
Dependencies are inferred from the claim text.