# US 8,129,357 B2 · Method of making and using an adenosine analogue

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- Number: US 8,129,357 B2
- Document ID: US8129357B2
- Status: Granted
- Kind: B2
- Application number: 11/999,637
- Filed: 2007-12-06
- Published: 2008-07-24
- Granted: 2012-03-06
- Earliest claimed: 2006-04-07
- Assignees: Academia Sinica
- Inventors: Yijuang Chern; Yun-Lian Lin; Nai-Kuei Huang; Jung-Hsing Lin; Jim-Min Fang; Chia-I Lin
- Web page: https://patentgrep.com/patent/US8129357B2

## CPC

- A61K 36/8988: Gastrodia
- A61K 31/7076: containing purines, e.g. adenosine, adenylic acid
- A61P 25/00: Drugs for disorders of the nervous system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.

## Claims

### Claim 1

A method of ameliorating or treating Huntington's disease in a mammalian subject in need thereof comprising administering the subject a pharmaceutical composition comprising an effective amount of purified or chemically synthesized N6-(4-hydroxybenzyl)adenosine or a pharmaceutical salt or solvate thereof as a pharmaceutical active agent.

### Claim 2 (depends on 1)

The method of claim 1 wherein N6-(4-hydroxybenzyl)adenosine is a chemically synthesized compound.

### Claim 3 (depends on 1)

The method of claim 1 wherein N6-(4-hydroxybenzyl)adenosine is a purified compound.

### Claim 4

A method of ameliorating or treating inflammation related to Huntington's disease in a mammalian subject in need thereof comprising administering the subject a pharmaceutical composition comprising an effective amount of purified or chemically synthesized N6-(4-hydroxybenzyl)adenosine or a pharmaceutical salt or solvate thereof as a pharmaceutical active agent.