Identification and monitoring of systemic lupus erythematosus
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsJoseph M. Ahearn, Susan M. Manzi, Jeannine Navratil
Life of this patent
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Abstract
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE and/or on platelets of the individual obtained at a different time. Kits for use in the above-described methods are provided along with computer readable media tangibly embodying executable instructions to perform the methods.
Claims13
A computer readable medium, storing computer-executable instructions for implementing an evaluation tool using an automated system, wherein the automated system comprises memory and a processor, and wherein the evaluation tool evaluates data corresponding to a determination of complement component C4d
- associated with platelets, the computer-executable instructions causing the processor to:
- receive data corresponding to the complement component C4d associated with platelets from an individual;
- store the data corresponding to complement component C4d in the memory of the automated system;
- store a retrieved a reference value for complement component C4d associated with platelets of individuals;
- and compare the received data with the reference value, wherein the computer-executable instructions further cause the processor to:
- determine if the individual has systemic lupus erythematosus based on the comparison of the received data and the reference value;
- and present the results of the determination.
A computer readable medium tangibly embodying executable instructions to perform a method for identifying systemic lupus erythematosus in an individual, the method comprising:
- quantitating complement C4d associated with platelets obtained from the individual;
- and
- comparing the quantity of complement C4d associated with platelets obtained from the individual with quantities of complement C4d associated with platelets obtained from individuals not having systemic lupus erythematosus, wherein the quantity of C4d associated with platelets obtained from the individual being higher as compared to quantities of C4d associated with platelets obtained from individuals not having systemic lupus erythematosus correlates with the presence of systemic lupus erythematosus in the patient.
A computer readable medium tangibly embodying executable instructions to perform a method for monitoring disease activity of systemic lupus erythematosus in an individual, the method comprising:
- quantitating complement C4d associated with platelets obtained from the individual;
- and
- comparing the quantity of complement C4d associated with platelets obtained from the individual with quantities of complement C4d associated with platelets obtained from either the individual at one or more different times or from individuals not having systemic lupus erythematosus;
- wherein quantities of C4d associated with platelets obtained from the individual being higher as compared to quantities of C4d associated with platelets obtained from either the individual at one or more different times or from individuals not having systemic lupus erythematosus correlates with the presence of systemic lupus erythematosus in the patient.
Dependencies are inferred from the claim text.