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US 8,124,799 B2Granted
Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
AssigneeReata Pharmaceuticals, Inc.
InventorsEric Anderson, Xin Jiang, Melean Visnick
Life of this patent
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Abstract
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Claims6
A compound of the formula:
- wherein:
- Y is hydroxy or NR1R2, wherein:
- R1 and R2 are independently:
- hydrogen or hydroxy;
- or
- alkyl(C≦12), alkenyl(C≦12), alkynyl(C≦12), aryl(C≦12), aralkyl(C≦12), heteroaryl(C≦12), heteroaralkyl(C≦12), acyl(C≦12), alkoxy(C≦12), alkenyloxy(C≦12), alkynyloxy(C≦12), aryloxy(C≦12), aralkoxy(C≦12), heteroaryloxy(C≦12), heteroaralkoxy(C≦12), thioacyl(C≦12), alkylsulfonyl(C≦12), alkenylsulfonyl(C≦12), alkynylsulfonyl(C≦12), arylsulfonyl(C≦12), aralkylsulfonyl(C≦12), heteroarylsulfonyl(C≦12), or heteroaralkylsulfonyl(C≦12), or a substituted version of any of these groups;
- or pharmaceutically acceptable salts, tautomers, or optical isomers thereof.
4 more elements
A compound of the formula:
Dependencies are inferred from the claim text.