Inactivating pathogens with oxidizing agents for vaccine production
AssigneeOregon Health & Science University
InventorsMark K. Slifka, Shirley V. Carter, Erika Hammarlund, Paul Yoshihara
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Abstract
The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided.
Claims13
A method for producing an immunogenic vaccine composition comprising an inactivated viral pathogen, the method comprising:
- contacting a viral pathogen with a solution comprising an oxidizing agent in an amount and for a time-period sufficient for the oxidizing agent to render the viral pathogen noninfectious while retaining viral immunogenicity, wherein said rendering is non-enzymatic;
- and
- verifying immunogenicity of the noninfectious virus using virus-specific antibody, B cell or T cell immunoassays, wherein producing an immunogenic vaccine composition comprising an inactivated viral pathogen is afforded.
Dependencies are inferred from the claim text.