Hereditary cataract status in canines based on HSF4 gene marker
AssigneeAnimal Health Trust
InventorsCathryn Suzanne Mellersh, Mark Vaudin
Life of this patent
Estimating the term…
Abstract
The invention provides methods for assessing the Hereditary cataract (HC) status of a canine mammal, which methods comprise use of an HSF4 marker to assess the status. Preferred canine mammals are dogs selected from the following breeds: Staffordshire bull terrier, Boston terrier, French bulldog, Mastiff, Bulldog, Boxer, Bullmastiff, Miniature bull terrier.
Claims16
A method for assessing the Hereditary cataract (HC) status of a Staffordshire bull terrier or French bulldog, or the juvenile HC status of a Boston terrier, comprising:
- a) providing a sample of nucleic acid comprising the HSF4 genomic sequence from the Staffordshire bull terrier, French bulldog, or Boston terrier;
- b) assaying the nucleic acid sample for an HSF4 marker wherein the HSF4 marker is a C insertion mutation at position 3034-3045 of SEQ ID NO:
- 10, wherein the C insertion mutation results in 11Cs;
- c) detecting the homozygous presence of the insertion mutation;
- and
- d) identifying the Staffordshire bull terrier or French bulldog as affected with HC or the Boston terrier as affected with juvenile HC.
A method for assessing the Hereditary cataract (HC) status of a Staffordshire bull terrier or French bulldog, or the juvenile HC status of a Boston terrier, comprising:
- a) providing a sample of nucleic acid comprising the HSF4 genomic sequence from the Staffordshire bull terrier, French bulldog, or Boston terrier;
- b) assaying the nucleic acid sample for an HSF4 marker wherein the HSF4 marker is a C insertion mutation at position 3034-3045 of SEQ ID NO:
- 10, wherein the C insertion mutation results in 11Cs;
- c) detecting the heterozygous presence of the insertion mutation;
- and
- d) identifying the Staffordshire bull terrier or French bulldog as a HC carrier or the Boston terrier as a carrier of juvenile HC.
Dependencies are inferred from the claim text.