Inactivated nodavirus vaccine
AssigneeNovartis AG
InventorsNuno Dos Santos, Jacqueline Ireland, Andrew Cartner Barnes, Michael Horne
Life of this patent
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Abstract
A vaccine against nodavirus infection in fish can be produced by inactivating the virus using an aziridine compound. This vaccine can be used to prevent Viral Nervous Necrosis (VNN) in a variety of fish species.
Claims8
An inactivated piscine viral nervous necrosis virus (NNV) strain Mt/01/Sba deposited with the ECACC under Accession No. 03060401, wherein the inactivated piscine viral nervous necrosis virus when administered to fish, is capable of providing a relative percent survival (RPS) of at least 50% after challenge with a non-inactivated NNV strain of Mt/01/Sba, and wherein the inactivated piscine viral nervous necrosis virus is inactivated with binary ethyleneimine.
A vaccine composition comprising:
- an inactivated piscine viral nervous necrosis virus (NNV) strain Mt/01/Sba deposited with ECACC under Accession No. 03060401;
- and
- a pharmaceutically acceptable carrier,
- wherein the inactivated piscine viral nervous necrosis virus is inactivated with binary ethyleneimine.
Dependencies are inferred from the claim text.