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AssigneeUniversity of Connecticut
InventorsLeo Lefrancois, Thomas A. Stoklasek
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The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.
A method for increasing proliferation of immune cells, comprising administering to a human an effective amount of a composition, wherein the composition comprises:
A method for driving homeostatic proliferation of lymphokine responsive immune cells, comprising administering to a human an effective amount of a composition, wherein the composition comprises:
Dependencies are inferred from the claim text.