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US 8,124,067 B2Granted
Method for immunotherapy of tumors
AssigneeIMBA-Institute Fur Molekulre Biotechnologie GmbH
InventorsJosef Penninger, Urs Eriksson
Life of this patent
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Abstract
A method for making dendritic cells reactive to an antigen comprises obtaining a sample of dendritic cells and contacting the cells with the antigen and at least one Toll-like receptor stimulant. Dendritic cells activated by this method provide a means for treating tumors and for creating animal models of autoimmune diseases.
Claims27
A method for making CD11c+ dendritic cells reactive to an antigen comprising:
- obtaining a sample of CD11c+ dendritic cells;
- and
- contacting the CD11c+ dendritic cells with at least one antigen, a CD40 stimulant, and at least one Toll-like receptor (TLR) stimulant, wherein the CD11c+ dendritic cells are contacted with the TLR stimulant for up to four hours.
Dependencies are inferred from the claim text.