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US 8,119,793 B2Granted
Process for preparing budesonide
AssigneeIndustriale Chimica S.R.L.
InventorsRoberto Lenna, Maurizio Montoro
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Abstract
A process is described for preparing budesonide which comprises the steps of: a) preparing an aqueous hydrochloric acid solution; b) reacting 16α-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere; c) quenching the reaction of step b) with water. The process of the invention enables the ratio between the A and B epimers of budesonide to be controlled.
Claims17
Process for preparing budesonide of formula (I),
- which comprises the steps of:
- a) preparing an aqueous hydrochloric acid solution;
- b) reacting 16α-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere;
- c) quenching the reaction of step b) with water or an aqueous solution.
1 more element
Dependencies are inferred from the claim text.