Back to results
US 8,119,593 B2Granted
Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin
AssigneeMannKind Corporation
InventorsPeter Richardson, Robert A. Baughman, Elizabeth Potocka, Anders Hasager Boss, Richard Petrucci
Life of this patent
Estimating the term…
Abstract
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
Claims33
A method of treating diabetes type 2, comprising:
- selecting a patient with diabetes type 2 currently being treated with a suppressor of hepatic glucose output but not a basal insulin who is in need of improved glycemic control and who would be a candidate for combination treatment with said suppressor of hepatic glucose output and an insulin secretagogue;
- and instead
- combining treatment with said suppressor of hepatic glucose output with routinely administering an ultrarapid acting insulin preparation with at least one established meal, wherein the suppressor of hepatic glucose is metformin.
A method of improving glycemic control in a type 2 diabetes patient currently taking a suppressor of hepatic glucose comprising administering to the patient a glycemic control regimen comprising:
- an ultrarapid acting insulin preparation, added instead of a sulfonylurea, and taken around a mealtime;
- wherein the patient continues to receive the daily suppressor of hepatic glucose, and the patient is not taking a basal insulin, wherein the suppressor of hepatic glucose is metformin.
Dependencies are inferred from the claim text.