Multivalent PCV2 immunogenic compositions and methods of producing such compositions
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsMichael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel
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Abstract
An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.
Claims22
A single dose multivalent combination vaccine comprising an immunogenic composition that comprises 4 μg to 400 μg recombinant PCV2 ORF2 protein per dose, at least one immunogenic active component against Mycoplasma hyopneumoniae, Porcine Reproductive and Respiratory Syndrome Virus, or a combination thereof, and a polymer of acrylic or methacrylic acid, wherein said single dose immunogenic composition provides protective immunity and is effective for lessening the severity of one or more clinical symptoms associated with PCV2 infection after the administration of a single dose of said immunogenic composition, compared to those swine not receiving said immunogenic composition and wherein said one or more clinical symptoms are selected from the group consisting of wasting, paleness of the skin, unthriftiness, respiratory distress, diarrhea, icterus, jaundice, lung lesions, nasal shedding, cough, diarrhea and combinations thereof.
Dependencies are inferred from the claim text.