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US 8,119,092 B2Granted
Pegylation and hydroxylation of trimetallic nitride endohedral metallofullerenes
AssigneeLuna Innovations Incorporated
InventorsZhongxin Ge, Harry C. Dorn, J. Paige Phillips
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Abstract
A pegylated and hydroxlated trimetallic nitride endohedral metallofullerene is provided comprising a plurality of hydroxyl groups and one or more polyethylene glycol (PEG) moieties covalently bonded to a fullerene encapsulating a trimetallic nitride. Methods of pegylation and hydroxylation of trimetallic nitride endohedral metallofullerene and methods of using pegylated and hydroxlated trimetallic nitride endohedral metallofullerene are described.
Claims10
An endohedral metallofullerene of the formula:
- A3−nXnN@Cm(—R(—[—O—CH2CH2—]k—Q)j)i(—OH)h;
- where A and X are metal atoms, n=0−3;
- m is an even number between about 60 and about 200;
- 1<h<m−2;
- i≧1;
- j=1 or 2;
- and k>1 wherein R is a malonyl group or an ethyl-malonyl group and Q is a methoxy group or a functional group selected from among an antigen, an antibody fragment, a membrane anchoring sequence, a polynucleotide, a receptor ligand, and biotin.
4 more elements
Dependencies are inferred from the claim text.