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US 8,114,967 B2Granted
Constructs and libraries comprising antibody surrogate light chain sequences
AssigneeSea Lane Biotechnologies, LLC
InventorsRamesh Bhatt, Lawrence Horowitz, Li Xu
Life of this patent
Estimating the term…
Abstract
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.
Claims1
A polypeptide comprising amino acid residues from 1 to about 116-126 of the VpreB1 sequence of SEQ ID NO:
- 1, fused directly, at its C-terminus to the N-terminus of amino acid residues from about 82-93 to 209 of the λ5 sequence of SEQ ID NO:
- 5, conjugated to an antibody heavy chain sequence comprising a variable region to form a conjugate, wherein the conjugate specifically binds a target.
Dependencies are inferred from the claim text.