Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents

A compound having the following formula VI:

• or a prodrug or pharmaceutically acceptable salt thereof,
• wherein:
• Q1 is —NR10R11;
• Q2 is
• each Q3 and Q4 is —OR7;
• Q5 is —OR8;
• each of R1, R6, R7 and R8 is, in each instance, H;
• each R2 and R10 is, independently, H, C1-C12 alkyl or substituted C1-C12 alkyl;
• R11 is cyano, C1-C12 alkyl, substituted C1-C12 alkyl, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl or —(CH2)n-(L1)m-(CH2)nn-E1;
• L1 is S, O or NJ1;
• n is an integer from 1 to 8;
• m is 0 or 1;
• nn is 0 or an integer from 1 to 8;
• mm is 1 or 2;
• E1 is H, hydroxyl, halogen, cyano, —NJ1J2, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl, C5-C20 aryl, substituted C5-C20 aryl, heteroaryl, substituted heteroaryl, a heterocyclic radical, a substituted heterocyclic radical or a substituted or unsubstituted mono or poly cyclic structure that is unsaturated, partially saturated or fully saturated and optionally includes one or more heteroatoms selected from O, N and S;
• each J1 and J2 is, independently, H, C1-C12 alkyl, substituted C1-C12 alkyl, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl, C5-C20 aryl, substituted C5-C20 aryl, —C(═O)—X, a heterocyclic radical or a substituted heterocyclic radical;
• each X is, independently, H, C1-C12 alkyl or substituted C1-C12 alkyl;
• and
• Z1 and Z2 are each, independently, H or —OH.