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US 8,114,838 B2Granted
Methods for protecting dopaminergic neurons from stress and promoting proliferation and differentiation of oligodendrocyte progenitors by NRG-2
AssigneeAcorda Therapeutics, Inc.
InventorMark Marchionni
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Abstract
The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel NRG-2 polypeptides and nucleic acid molecules.
Claims6
A method for protecting dopaminergic neurons from damage, said method comprising:
- contacting the dopaminergic neurons with a recombinant NRG-2 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:4 in an amount that promotes survival of dopaminergic neurons under stress.
A method for promoting mitogenesis and differentiation of oligodendrocyte progenitors or for promoting survival of oligodendrocytes, said method comprising:
- administering a recombinant NRG-2 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:4 to the oligodendrocyte progenitors or oligodendrocytes, wherein said administering elicits mitogenesis and differentiation of oligodendrocyte progenitors or promotes survival of oligodendrocytes.
Dependencies are inferred from the claim text.