Polypeptoid pulmonary surfactants
AssigneesNorthwestern University, Chiron Corporation
InventorsAnnelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
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Abstract
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
Claims7
A protein-analog compound that is a structural and functional mimic of lung surfactant protein-C, said compound comprising a monomer sequence of at least about 21 residues, said residues comprising at least one N-substituted glycine residue, said compound comprising a C-terminal hydrophobic component comprising at least about 12 of said residues in a helical structure, said compound is a polypeptoid selected from the compounds of FIG. 7c.
A protein-analog compound selected from the compounds of FIGS. 7a-7c.
A pulmonary surfactant composition comprising a protein-analog compound that is a structural and functional mimic of lung surfactant protein-C, said compound comprising a monomer sequence of at least about 21 residues, said residues comprising at least one N-substituted glycine residue, said compound comprising a C terminal hydrophobic component comprising at least about 12 of said residues in a helical structure, and a component selected from naturally-occurring phospholipids, non natural analogs of said phospholipids, commercial surface active agents and combinations thereof, said compound is a peptoid-peptide chimera compound selected from the compounds of FIGS. 7a-b and combinations thereof, said composition having physiological alveolar surface activity.
Dependencies are inferred from the claim text.