Compositions and methods for treatment of cervical cancer
AssigneeThe Trustees of the University of Pennsylvania
InventorsYvonne Paterson, John Rothman
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Abstract
The present invention provides methods of treating, protecting against, and inducing an immune response against cervical cancer, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and an E7 and/or E6 antigen. The present invention also provides methods for inducing an anti-E7 response in a human subject and treating HPV-mediated diseases, disorders, and symptoms comprising administration of the recombinant Listeria strain.
Claims15
A method of treating a late stage cervical cancer in a human patient having said late stage cancer, comprising the step of administering to said patient a recombinant Listeria strain, said recombinant Listeria strain comprising a recombinant polypeptide comprising an N-terminal fragment of an LLO protein fused to a Human Papilloma Virus (HPV) E7 antigen, whereby said recombinant Listeria strain induces an immune response against said E7 antigen, thereby treating a late stage cervical cancer in a human patient.
Dependencies are inferred from the claim text.