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US 8,114,383 B2Granted
Abuse-proofed dosage form
AssigneeGruenenthal GmbH
InventorsJohannes Bartholomäus, Heinrich Kugelmann, Elisabeth Arkenau-Marić
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Abstract
The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
Claims9
A thermoformed dosage form comprising:
- i) one or more active ingredients with abuse potential (A) selected from the group consisting of opiates and opioids,
- ii) optionally physiologically acceptable auxiliary substances (B),
- iii) at least 30% by weight of polyalkylene oxide (C) having a molecular weight of 1-15 million according to rheological measurements, and
- iv) optionally at least one wax (D),
- wherein said dosage form has a breaking strength of at least 500 N and wherein the active ingredient with abuse potential (A) is present in a controlled release matrix of component (C).
2 more elements
Dependencies are inferred from the claim text.