Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
AssigneeRegulus Therapeutics Inc.
InventorsC. Frank Bennett, Susan M. Freier, Richard H. Griffey
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Abstract
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
Claims25
A method of inhibiting the activity of a microRNA comprising contacting a cell comprising the microRNA with a compound comprising an oligomeric compound, wherein:
- the oligomeric compound is at least 90% complementary to a miRNA or a precursor thereof;
- the oligomeric compound consists of 15 to 30 linked monomeric subunits;
- at least one monomeric subunit is a modified nucleoside;
- and
- the miRNA is selected from miR-21 (SEQ ID NO:
- 64) and miR-1 (SEQ ID NO:
- 29).
A composition comprising a compound comprising an oligomeric compound, wherein:
- the oligomeric compound is at least 90% complementary to a miRNA or a precursor thereof;
- the oligomeric compound consists of 15 to 30 linked monomeric subunits;
- at least one monomeric subunit is a modified nucleoside;
- and
- the miRNA is selected from miR-21 (SEQ ID NO:
- 64) and miR-1 (SEQ ID NO:
- 29);
- and a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.