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US 8,110,549 B2Granted
Alpha-conotoxin peptides
AssigneeUniversity of Utah Research Foundation
InventorsMaren Watkins, Baldomero M. Olivera, David R. Hillyard, J. Michael McIntosh, Robert M. Jones
Life of this patent
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Abstract
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
Claims7
An isolated pure α-conotoxin peptide comprising the amino acid sequence of:
- Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Val-Asn-His-Xaa5-Xaa1-Leu-Cys (SEQ ID NO:34);
- wherein Xaa1 is Glu or γ-carboxy-Glu (Gla) and Xaa5 is Pro or hydroxy-Pro;
- wherein the C-terminus contains a hydroxyl group or an amide group;
- wherein the His residue may be substituted with a halo-His residue;
- and wherein the Cys residues may be in the D or L configuration or substituted with homocysteine in the D or L configuration.
2 more elements
An isolated pure α-conotoxin peptide precursor comprising the amino acid sequence of SEQ ID NO:111.
Dependencies are inferred from the claim text.