Chronic access system for extracorporeal treatment of blood including a continously wearable hemodialyzer

Apparatus for the controlled introduction of a liquid medicament into the vascular system of a patient, comprising:

• (a) first and second cuffs, each of said cuffs comprising first and second superposed sheets of flexible plastic film selectively bonded to one another to define at least first and second fluid flow paths there between, the first fluid flow path including an expandable and compressible chamber, the second fluid flow path including a reservoir configured to contain the liquid medicament, said cuffs adapted to surround and be supported by a person's limb;
• (b) a first cannula configured for insertion into a blood vessel selectively sequentially exposed to arterial blood pressure and venous blood pressure and a second cannula configured for insertion into a blood vessel exposed to only venous blood pressure, the first cannula being coupled to an inlet of the first fluid flow path on the first and second flexible cuffs and the second cannula being coupled to an outlet of the first fluid flow path on the first and second cuffs;
• (c) a pump device configured to be driven by expansion and compression of the expandable and compressible chamber in said first fluid flow path;
• (d) a dialyzer coupled to the first and second flexible cuffs, the dialyzer comprising a liquid impervious housing containing a plurality of semi-permeable membranous walls and where the first and second cannulae are in fluid communication with a flow path through the dialyzer;
• and
• (e) the housing includes an outlet port and the first and second cuffs include a third fluid flow path leading from the housing outlet port to a fluid collection container.