Process for the production of compounds via hazardous intermediates in a series of microreactors
AssigneeDsm IP Assets B.V.
InventorsRafael Wilhelmus Elisabeth Ghislain Reintjens, Quirinus Bernardus Broxterman, Martina Kotthaus, Peter Poechlauer
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Abstract
Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.
Claims16
A multi-step process for the preparation of an amine compound via a hazardous organic azide intermediate, comprising the steps of:
- a) reacting N3− in a continuous microreactor with an organic compound suitable for reaction with N3− to form a corresponding organic azide,
- b) optionally performing one or more reaction steps on the organic azide in one or more additional microreactors, and
- c) further reducing the organic azide with a suitable reducing agent in a subsequent continuous microreactor to form an amine compound.
A multi-step process for the preparation of an amine compound via a hazardous organic azide intermediate, comprising the steps of:
- a) reacting N3− in a first continuous microreactor with an organic compound suitable for reacting with N3− to form a corresponding organic azide, and
- b) directly further reducing the formed organic azide with a suitable reducing agent in a second continuous microreactor to form an amine compound.
A multi-step process for the preparation of alcohol, aldehyde or ketone compounds, optionally protected as the hydrate, hemiacetal or acetal, via hazardous organic peroxide or hydroperoxide intermediates, comprising the steps of:
- a) reacting in a continuous microreactor an organic compound suitable for reacting with hydrogen peroxide, ozone or (singlet) oxygen, with hydrogen peroxide, ozone or (singlet) oxygen to form a corresponding hazardous organic peroxide or hydroperoxide intermediate,
- b) optionally performing one or more reaction steps on the hazardous organic peroxide or hydroperoxide intermediate in one or more additional microreactors, and
- c) further reducing the hazardous organic peroxide or hydroperoxide intermediate with a suitable reducing agent in a subsequent continuous microreactor to form a stable alcohol, or a stable aldehyde or ketone compound, optionally protected as the hydrate, hemiacetal or acetal.
A multi-step process for the preparation of alcohol, aldehyde or ketone compounds, optionally protected as the hydrate, hemiacetal or acetal, via hazardous organic peroxide or hydroperoxide intermediates, comprising the steps of:
- a) reacting in a continuous microreactor an organic compound suitable for reacting with hydrogen peroxide, ozone or (singlet) oxygen, with hydrogen peroxide, ozone or (singlet) oxygen to form a corresponding hazardous organic peroxide or hydroperoxide intermediate, and
- b) directly further reducing the hazardous organic peroxide or hydroperoxide intermediate with a suitable reducing agent in a second continuous microreactor to form a stable alcohol, or a stable aldehyde or ketone, optionally protected as the hydrate, hemiacetal or acetal.
Dependencies are inferred from the claim text.