Antimicrobial composition
AssigneeDairy Australia Limited
InventorsEric Charles Reynolds, Stuart Geoffrey Dashper, Rita Ann Paolini
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA technology and a divalent cation.
Claims17
An antimicrobial composition, the composition comprising an aqueous solvent and having a divalent cation and a peptide dissolved therein, wherein the divalent cation is added to the solvent such that substantially all of the divalent cation is dissolved in the solvent, wherein the divalent cation is a Ca2+ or a Zn2+ ion,
- and wherein the peptide is non-glycosylated, has a length of less than about 100 amino acids, and comprises an amino acid sequence selected from the group consisting of:
- Ala Val Glu Ser Thr Val Ala Thr Leu Glu Ala X Pro Glu Val Ile Glu Ser Pro Pro Glu (SEQ ID NO:1);
- and
- Ala Val Glu Ser Thr Val Ala Thr Leu Glu Asp X Pro Glu Val Ile Glu Ser Pro Pro Glu (SEQ ID NO:2),
- wherein amino acid residue X is a phosphoseryl residue.
A method of treatment, comprising:
- a) administering to a subject a therapeutically effective amount of a formulation comprising:
- an aqueous solvent and having a divalent cation and a peptide dissolved therein, wherein the divalent cation is added to the solvent such that substantially all of the divalent cation is dissolved in the solvent, wherein the divalent cation is a Ca2+ or a Zn2+ ion,
- and wherein the peptide is non-glycosylated, has a length of less than about 100 amino acids, and comprises an amino acid sequence selected from the group consisting of:
- Ala Val Glu Ser Thr Val Ala Thr Leu Glu Ala X Pro Glu Val Ile Glu Ser Pro Pro Glu (SEQ ID NO:1);
- and
- Ala Val Glu Ser Thr Val Ala Thr Leu Glu Asp X Pro Glu Val Ile Glu Ser Pro Pro Glu (SEQ ID NO:2),
- wherein amino acid residue X is a phosphoseryl residue ;and
- b) allowing the formulation to act on the subject in a manner which prevents a disease selected from the group consisting of dental caries and periodontal disease.
Dependencies are inferred from the claim text.