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US 8,106,001 B2Granted
Diagnostic markers of human female infertility
AssigneeUniversity of South Florida
InventorsSiamak Tabibzadeh, Ravi Kothapalli
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AssigneeUniversity of South Florida
InventorsSiamak Tabibzadeh, Ravi Kothapalli
Estimating the term…
The subject invention pertains to methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for contraception. Methods and compounds are based on the levels of ebaf in endometrial tissue. Methods for diagnosing endometrial receptivity and bleeding function by screening a biological sample such as an endometrial tissue sample, or bodily fluid for the presence of ebaf. A contraceptive compound containing an effective amount of ebaf and a pharmaceutically acceptable carrier. A diagnostic kit for timing contraception containing reagents for screening a sample for the presence of ebaf. A method of treating endometrial irregularities by down-regulating the expression of ebaf.
A contraceptive composition comprising an effective amount of a human ebaf protein in a pharmaceutically-acceptable carrier, wherein the human ebaf has a molecular weight of about 41 kD and comprises the amino acid sequence shown in SEQ ID NO:
A method for preventing pregnancy in a female animal, comprising administering to the female animal an effective amount of a contraceptive composition comprising an effective amount of a protein an human ebaf protein in a pharmaceutically-acceptable carrier, wherein the human ebaf protein has a molecular weight of about 41 kD and comprises the amino acid sequence shown in SEQ ID NO:
Dependencies are inferred from the claim text.