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US 8,105,817 B2Granted
Methods and systems for toxin delivery to the nasal cavity
AssigneeThe Foundry, LLC
InventorsMark E. Deem, Hanson Gifford
Life of this patent
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Abstract
Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
Claims30
A system for delivering toxins to target cells in a nasal membrane, said system comprising:
- a catheter adapted to introduce a toxin to a region proximate the target cells;
- an energy applicator configured for applying energy to the target cells under conditions which cause poration of the cell membranes to enhance delivery of the toxin;
- and
- a source of toxin suitable for introduction from the catheter, wherein the toxin comprises a light chain fragment of a neurotoxin and being substantially free of heavy chain fragments of the neurotoxin.
1 more element
Dependencies are inferred from the claim text.