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US 8,105,603 B2Granted
Polypeptides that bind APRIL
AssigneeGenentech, Inc.
InventorsRobert F. Kelley, Darshana Ramesh Patel
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Abstract
The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of APRIL/BAFF binding to BCMA and APRIL/BAFF signaling.
Claims26
An isolated polypeptide that binds APRIL comprising the following sequence:
- C-S-Q-N-E-Y-F-D-S-L X11-H-A-C-X15-P-C-X18-L-X20-C-S-S-N-T-P-P-L-T-C-Q-R-Y-C (SEQ ID NO:
- 34) wherein X11 is L, I, or V;
- wherein X15 is I, A, or K;
- wherein X18 is Q or D;
- and wherein X20 is R or Y and wherein the sequence does not comprise the sequence
- (SEQ ID NO:
- 35)
- CSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYC.
5 more elements
Dependencies are inferred from the claim text.