Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M Wilson, Guangping Gao, Soumitra Roy
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Abstract
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Claims17
A recombinant adenovirus having a capsid comprising an AdPan6 hexon protein having the amino acid sequence of SEQ ID NO:7, said adenovirus further comprising a nucleic acid sequence heterologous to AdPan6.
A recombinant adenovirus having a capsid comprising a chimeric adenovirus hexon protein containing a fragment of the AdPan6 hexon protein the adenovirus further comprising a nucleic acid sequence heterologous to the AdPan6, wherein the fragment of the AdPan6 hexon protein is the AdPan6 hexon protein of SEQ ID NO:7 with an N-terminal or a C-terminal truncation of about 50 amino acids in length or is selected from the group consisting of:
- the amino acid residues 125 to 443 of SEQ ID NO:7;
- the amino acid residues 138 to 441 of SEQ ID NO:7;
- the amino acid residues 138 to 163 of SEQ ID NO:7;
- the amino acid residues 170 to 176 of SEQ ID NO:7;
- and the amino acid residues 404 to 430 of to SEQ ID NO:
- 7.
A recombinant adenovirus having a capsid comprising an AdPan6 hexon protein having the amino acid sequence of SEQ ID NO:
- 7, said capsid encapsidating a heterologous nucleic acid sequence operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell.
A recombinant adenovirus having a chimeric adenovirus capsid comprising a hexon protein of Pan6 having the sequence of SEQ ID NO:7 and a heterologous adenovirus capsid protein sequence.
Dependencies are inferred from the claim text.