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US 8,101,782 B2Granted
Compounds that inhibit cholinesterase
AssigneeCoLucid Pharmaceuticals, Inc.
InventorsNadia M. J. Rupniak, James F. White, Kazumi Shiosaki, J. David Leander, Shoucheng Du, Daniel J. Coughlin
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Abstract
Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The compounds of the invention are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.
Claims6
A compound according to formula I:
- pharmaceutically acceptable salt wherein
- Q is selected from:
- R1 is selected from hydrogen and unsubstituted alkyl, or R1 is absent;
- R3, R4 and R5 are each, independently selected from unsubstituted alkyl and hydrogen.
1 more element
A compound selected from compounds:
Dependencies are inferred from the claim text.