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US 8,101,640 B2Granted
Antibacterial agents
AssigneesNovartis Vaccines and Diagnostics, Inc., University of Washington
InventorsNiels H. Andersen, Jason Bowman, Alice Erwin, Eric Harwood, Toni Kline, Khisimuzi Mdluli, Simon Ng, Keith B. Pfister, Ribhi Shawar, Allan S. Wagman, Asha Yabannavar
Life of this patent
Estimating the term…
Abstract
Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
Claims10
A compound having the formula XIII:
- or a stereoisomer, pharmaceutically acceptable salt, ester, or prodrug thereof, wherein R4 is selected from the group consisting of
- (1) H,
- (2) substituted or unsubstituted Ci-C6-alkyl,
- (3) C1-C6-alkyl substituted with aryl,
- (4) C1-C6-alkyl substituted with heterocyclyl, and
- (5) C1-C6-alkyl substituted with heteroaryl;
- A is H or —CH(CH3)OH;
- R1 is H or substituted or unsubstituted C1-6-alkyl;
- R2 is selected from the group consisting of
- (1) H,
- (2) substituted or unsubstituted C1-C6-alkyl,
- (3) substituted or unsubstituted aryl,
- (4) substituted or unsubstituted heterocyclyl,
- (5) substituted or unsubstituted heteroaryl,
- (6) C1-C6-alkyl substituted with aryl,
- (7) C1-C6-alkyl substituted with heterocyclyl,
- (8) C1-C6-alkyl substituted with heteroaryl,
- or R1 and R2 together with the N atom to which they are attached can form a substituted or unsubstituted heterocyclic ring, having from 3 to 10 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S.
15 more elements
Dependencies are inferred from the claim text.