US 8,101,597 B2 · Quetiapine salts and their polymorphs

Abstract

The present invention relates to novel and stable salt forms of quetiapine, processes for preparation, pharmaceutical compositions, and method of treating thereof. More particularly, the present invention provides novel acid addition salts of quetiapine wherein the acid counter ion is provided by an acid selected from the group consisting of benzene sulfonic acid, dibenzoyl-L-(+)-tartaric acid and di-p-toluoyl-L-(+)-tartaric acid. The present invention also provides novel polymorphic forms of quetiapine salts selected from the group consisting of quetiapine hydrobromide, quetiapine sulfate, quetiapine nitrate and quetiapine citrate.

Claims8

Dependent claims

Solid state form of quetiapine sulfate salt characterized by one or more of the following properties:

i) a powder X-ray diffraction pattern substantially in accordance with FIG. 6;
ii) a powder X-ray diffraction pattern having peaks at about 6.3, 8.1, 8.7, 9.7, 10.8, 12.4, 15.7, 17.8, 18.5, 19.4, 19.8, 20.1, 20.7, 21.2, 21.7, 22.9, 24.7, 25.0, 25.6, 25.9 and 26.2±0.2 degrees 2-theta;
and
iii) a powder X-ray diffraction pattern having additional peaks at about 8.9, 12.1, 12.6, 13.9, 14.1, 16.5, 18.2, 18.8 and 22.2±0.2 degrees 2-theta.

1 more element

Dependencies are inferred from the claim text.

Quetiapine salts and their polymorphs

Life of this patent

Quetiapine salts and their polymorphs

Life of this patent

Abstract

Claims8