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AssigneeFolia Biotech Inc.
InventorsDenis Leclerc, Nathalie Majeau, Constantino III Roberto Lopez-Macias, Alain Lamarre
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An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
An immunopotentiating composition comprising one or more immunogens and an adjuvant, the adjuvant comprising
A recombinant fusion protein comprising PapMV coat protein and one or more immunogens fused to the C-terminus of said coat protein, wherein said recombinant fusion protein is capable of self-assembly to form virus-like particles (VLPs).
A recombinant PapMV coat protein comprising an amino acid sequence as set forth in SEQ ID NO:1 in which glutamate at position 128 has been substituted for a neutral amino acid.
Dependencies are inferred from the claim text.