Compositions for conferring tolerance to viral disease in social insects, and the use thereof
AssigneeBeelogics Inc.
InventorsNitzan Paldi, Gal Yarden
Life of this patent
Estimating the term…
Abstract
Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
Claims23
An isolated nucleic acid agent comprising an IAPV-specific double stranded ribonucleic acid (RNA) consisting of SEQ ID NO:
- 34 and an RNA sequence complementary to the entire SEQ ID NO:
- 34.
A method for reducing the susceptibility of a bee to a disease caused by Israel Acute Paralysis Virus (IAPV) comprising feeding the bee a composition consisting of bee feed and an effective amount of a nucleic acid agent comprising an IAPV-specific double stranded ribonucleic acid (RNA) consisting of SEQ ID NO:
- 34 and an RNA sequence complementary to the entire SEQ ID NO:
- 34, thereby reducing the susceptibility of said bee to a disease caused by IAPV.
A method of reducing the susceptibility of honeybees to Colony Collapse Disorder (CCD), the method comprising feeding to the honeybee colony a bee-ingestible composition consisting of bee feed and an effective amount of a nucleic acid agent comprising an Israel Acute Paralysis Virus-specific double stranded ribonucleic nucleic acid (RNA) consisting of SEQ ID NO:
- 34 and an RNA sequence complementary to the entire SEQ ID NO:
- 34, thereby reducing the susceptibility of said honeybees to CCD.
Dependencies are inferred from the claim text.