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US 8,097,585 B2Granted
Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsFritz H. Bach, Pascal O. Berberat, Simon C. Robson
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Abstract
The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products.
Claims31
A method of treating an inflammatory disorder in a patient in need thereof, wherein the method comprises
- administering to said patient a composition comprising a pharmaceutically acceptable carrier and at least one agent selected from the group consisting of:
- heme oxygenase-1 (HO-1), bilirubin, biliverdin, ferritin, iron, desferoxamine, salicylaldehyde isonicotinoyl hydrazone, iron dextran, and apoferritin, wherein the composition is administered in an amount sufficient to treat the inflammatory disorder;
- and wherein the inflammatory disorder is localized in the gastrointestinal tract and is selected from the group consisting of:
- amoebic dysentery, bacillary dysentery, schistosomiasis, campylobacter enterocolitis, yersinia enterocolitis, enterobius vermicularis, radiation enterocolitis, ischaemic colitis, eosinophilic gastroenteritis, ulcerative colitis, indeterminate colitis, and Crohn's disease.
1 more element
A method of treating an inflammatory disorder in a patient in need thereof, wherein the method comprises
- administering to said patient a composition comprising a pharmaceutically acceptable carrier and at least one agent selected from the group consisting of:
- heme oxygenase-1 (HO-1), bilirubin, biliverdin, ferritin, iron, desferoxamine, salicylaldehyde isonicotinoyl hydrazone, iron dextran, and apoferritin, wherein the composition is administered in an amount sufficient to treat the inflammatory disorder, and wherein the inflammatory disorder is characterized by free radical damage.
Dependencies are inferred from the claim text.