Methods and compositions for imaging
AssigneeMount Sinai School of Medicine
InventorsEdward A. Fisher, Zahi A. Fayad, Kevin J. Williams
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Abstract
The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent linked through a chelator to a component of the nanoparticle, wherein the one metallic or non-metallic contrast agent is present in an amount of between 5% to about 50% (w/w) of the nanoparticle, and the nanoparticle has a diameter of from about 5 nm to about 50 nm. Compositions and kits comprising the synthetic nanoparticles and methods of making and using the same are also provided.
Claims58
A synthetic nanoparticle, said synthetic nanoparticle comprising:
- at least one apolipoprotein, said at least one apolipoprotein is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent linked through a chelator to a component of said nanoparticle, said at least one metallic or non-metallic contrast agent being present in an amount of between 5% to about 50% (w/w) of said nanoparticle, and said synthetic nanoparticle having a diameter of from about 5 nm to about 50 nm.
A synthetic nanoparticle, said synthetic nanoparticle comprising:
- at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent sequestered in the core of said synthetic nanoparticle.
Dependencies are inferred from the claim text.