Back to results
US 8,097,256 B2Granted
Cancer vaccines and vaccination methods
AssigneeCedars-Sinai Medical Center
InventorsJohn S. Yu, Gentao Liu, Keith L. Black
Life of this patent
Estimating the term…
Abstract
Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
Claims8
A method for treating a neural cancer in a patient, the method comprising:
- administering to the patient a composition comprising dendritic cells, wherein the dendritic cells present on their surface peptide epitopes comprising amino acid sequences corresponding to epitopes of the following six antigens:
- tyrosinase-related protein (TRP)-2, Melanoma-associated Antigen-1 (MAGE-1), HER-2, interleukin-13 receptor α2 (IL-13 receptor α2), gp100, and Antigen isolated from Immunoselected Melanoma-2 (AIM-2), wherein at least one of the peptide epitopes is a superagonist peptide epitope, and wherein the dendritic cells acquired the peptide epitopes in vitro by exposure to synthetic peptides comprising the peptide epitopes, and wherein the peptide epitopes comprise the following sequences:
- RSDSGQQARY
- (SEQ ID NO:
- 3) from AIM-2;
- EADPTGHSY
- (SEQ ID NO:
- 4) from MAGE-1;
- SVYDFFVWL
- (SEQ ID NO:
- 5) from TRP-2;
- IMDQVPFSV
- (SEQ ID NO:
- 67) from gp100;
- VMAGVGSPYV
- (SEQ ID NO:
- 37) from HER-2;
- and
- WLPFGFILI
- (SEQ ID NO:
- 8) from IL-13 receptor α2.
18 more elements
Dependencies are inferred from the claim text.